Further, we show that the image quality achieved allows to assess the neuropathology of multiple sclerosis in a biopsy sample collected during surgery. Apart from unstained and paraffin-embedded tissue, we tested hydrated tissue, as well as heavy metal stained and resin-embedded tissue using two different protocols. We present examples for different optical configurations using state-of-the art synchrotron instruments for holographic tomography, as well as compact laboratory setups for phase-contrast tomography in the direct contrast (edge-enhancement) regime. In this work, we optimize the setups and experimental parameters of X-ray phase-contrast computed-tomography for the three-dimensional imaging of the cyto- and myeloarchitecture of cerebral cortex, including both human and murine tissue. Note: Author names will be searched in the keywords field, also, but that may find papers where the person is mentioned, rather than papers they authored.Use a comma to separate multiple people: J Smith, RL Jones, Macarthur.Use these formats for best results: Smith or J Smith.For best results, use the separate Authors field to search for author names.Use quotation marks " " around specific phrases where you want the entire phrase only.Question mark (?) - Example: "gr?y" retrieves documents containing "grey" or "gray".Asterisk ( * ) - Example: "elect*" retrieves documents containing "electron," "electronic," and "electricity".Improve efficiency in your search by using wildcards.Example: (photons AND downconversion) - pump.Example: (diode OR solid-state) AND laser.Note the Boolean sign must be in upper-case. Separate search groups with parentheses and Booleans.Keep it simple - don't use too many different parameters.